The enzymes involved in lysine methylation have been first found to focus on histone and thus had been initially named histone methyltransferases and histone demethylases, following the naming mannequin for histone acetyltransferase and histone deacetylase.

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nove.teamA protein sequence alignment of the SET domains of a number of consultant histone lysine methyltransferases (HKMT) grouped in line with their histone-lysine specificity.

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Methylation of particular histone lysine residues serves as a publish-translational epigenetic modification that controls the expression of genes by serving as 'markers' for the recruitment of particular complexes that direct the group of chromatin.

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